Serum lipid profiling in decompensated patients with Hepatitis B virus -related cirrhosis

Volume 8, Issue 5, October 2023     |     PP. 361-369      |     PDF (211 K)    |     Pub. Date: October 7, 2023
DOI: 10.54647/cm321189    73 Downloads     245470 Views  

Author(s)

Changzhi Xu, Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen university, Guangzhou, Guangdong 510530, P.R.China
Yanhua Yi, Department of Emergency, Third Affiliated Hospital of Sun Yat-sen university, Guangzhou, Guangdong 510530, P.R.China
Zhizhi Xie, Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen university, Guangzhou, Guangdong 510530, P.R.China
Donglin Zhu, Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen university, Guangzhou, Guangdong 510530, P.R.China
Zhu Wang, Department of Urology, Affiliated Longhua People's Hospital, Southern Medical University, Shenzhen, Guangdong 510080, P.R.China
Yun Xi, Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen university, Guangzhou, Guangdong 510530, P.R.China

Abstract
Background: The association of lipid profile with decompensation in patients with liver cirrhosis has not been clarified. The present study aimed to investigate the impact of Hepatitis B virus (HBV) infection on the lipid profile in decompensated patients with hepatitis B cirrhosis.
Methods: A total of 178 HBV-related decompensated cirrhosis (HBV-DeCi) patients were included in this retrospective analysis. The included patients were subdivided into 4 groups: 24 patients with HBsAg, HBeAg and HBcAb positive were set as group Ia; 14 patients with HBsAg, HBeAg ,HBeAb and HBcAb positive were set as group Ib;112 patients with HBsAg, HBeAb and HBcAb positive were set as group II; 28 patients with HBsAb, HBeAb and HBcAb positive were set as group III. Lipid profile included total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein- cholesterol (LDL-c), triglycerides (TG), and lipoprotein(a) (Lpa) were analyzed respectively. The difference between mentioned groups and the HBV infection were characterized respectively.
Results: Our data showed that the values of TG in group Ia was 1.2181 ± 0.1898 (mmol/L), in Ib was 1.306 ± 0.1702 (mmol/L), in Ia+Ib was 1.29 ± 0.1338 (mmol/L), and in group III was 0.8950±0.07200 (mmol/L). There were significant differences between group Ia and III (P=0.0498), Ib and III (P=0.0125) and also between group Ia+Ib and III (P=0.0217).
Conclusions: Serum TG levels are closely related to the HBV infection in HBV-DeCi patients. It may be used as a new indicator of advanced liver disease and cirrhosis recompensation.

Keywords
hepatitis B virus, decompensated cirrhosis, Lipid profile

Cite this paper
Changzhi Xu, Yanhua Yi, Zhizhi Xie, Donglin Zhu, Zhu Wang, Yun Xi, Serum lipid profiling in decompensated patients with Hepatitis B virus -related cirrhosis , SCIREA Journal of Clinical Medicine. Volume 8, Issue 5, October 2023 | PP. 361-369. 10.54647/cm321189

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