SYNTHESIS AND CHARACTERIZATION OF NEW COMPLEX HETEROCYCLIC RING SYSTEMS OF INDUSTRIAL IMPORTANCE

Volume 1, Issue 1, October 2016     |     PP. 57-66      |     PDF (450 K)    |     Pub. Date: December 20, 2016
DOI:    464 Downloads     7620 Views  

Author(s)

Ayuk Eugene Lakem, Industrial Chemistry Unit, Chemical Science Department, Godfrey Okoye University, Ugwuomu-Nike, Enugu, Nigeria
Nweke Cletus Mgadiugha, Industrial Chemistry Unit, Chemical Science Department, Godfrey Okoye University, Ugwuomu-Nike, Enugu, Nigeria
Ugwu Marigoretti Oge, Industrial Chemistry Unit, Chemical Science Department, Godfrey Okoye University, Ugwuomu-Nike, Enugu, Nigeria

Abstract
The synthesis and characterization of new complex monoaza and pentaaza angular phenothiazine derivatives is reported. The first derivative, 6,10-Dichloro-17-azadibenzo[a,n]triphenodithiazin-5,11-dione10 was obtained by a base-catalyzed reaction of 2,6-diaminopyridine-3,5-dithiol 5and 2,3-dichloro-1,4-naphthaquinone 9, while that of the second derivative, 7,9,15,17-tetraamino-6,8,16,18,25-pentazadibenzo[a,n]di([1,4]benzothaizino[3,2-c,l])triphenodiathizine (11) was achieved by the reaction of two moles of 2, 4, 6-triaminopyrimidine-3-thiol (8) and one mole compound (10) under the same reaction conditions.. The assigned structures to the above synthesized compounds were done on the basis of spectroscopic analysis.

Keywords
Monoaza, Pentaaza, Triphenodiathiazin, Triaminopyrimidine-3-thiol, Phenothiazine.

Cite this paper
Ayuk Eugene Lakem, Nweke Cletus Mgadiugha, Ugwu Marigoretti Oge, SYNTHESIS AND CHARACTERIZATION OF NEW COMPLEX HETEROCYCLIC RING SYSTEMS OF INDUSTRIAL IMPORTANCE , SCIREA Journal of Chemistry. Volume 1, Issue 1, October 2016 | PP. 57-66.

References

[ 1 ] Odin E.M; Onoja P.K. and Saleh J.F; Synthesis, characterization and neuropharmacological activity of angular pentacyclic phenothiazine. Int. J. Phy. Sc. 8 (26), 1374-1381, 2013
[ 2 ] Sinha Shweta; Pandeja S.N; Verma Anopam; Yadav Deepika. Synthesis and biological activity of phenothiazine derivatives; , Int. J Research in Ayurveda & Pharm. 2 (4), 1130-1137, 2011
[ 3 ] Upendra Kumar; Kushwaha Yashovardhan; Sudhir Kumar Bhati and Asohok Kumar. Synthesis of new 10-substituted phenothiazines as Inflammatory and Analgesic Agents; Int. J. Pharm and Bio. Science, 1 (3), 1-10, 2010
[ 4 ] Okafor C.O. Chemistry and applications of angular phenothiazines. Dyes and Pigments,7 (4), 249-287, 1986.
[ 5 ] Massie S.P. The Chemistry of Phenothiazines. Chem. Rev, 54; 797-833, 1954.
[ 6 ] Massie S.P; Kadaba P.K; Ring Derivatives of Phenothiazines . The Synthesis of 1-substituted phenothiazines by Thionation; J. Org. Chem. 21: 347-348, 1956.
[ 7 ] Okafor C.O; Okerulu I.O; Okeke S.I; Vat dyes from new heterocyclic ring systems .Dyes and Pigments,8, 11–24, 1987
[ 8 ] B. E. Ezema, C. O. Okafor, C.G. Ezema and A.E. Onoabedje.Synthesis of new diaza angular and tetraazacomplex phenothiazine rings. Chemical and Processing Engineering Research,3, 40-47, 2012
[ 9 ] U.C. Okoro and B. E. Ezema; Synthesis of new non-linear diazaphenothiazine ring system. Int.Jour. Chem. 16, (2), 115-120, 2006
[ 10 ] Okoro U.C; The first analogues of dibenzotriphenodithiazine ring systems. Ind. J. Chem. 30B (118), 22-24, 1991
[ 11 ] B. E. Ezema; C.E. Ezema; D.I.Ugwu; Synthesis of a new and first triazadibenzo[a,n] triphenodithiazine. Chemical and Processing Engieering Research, 8, 35-41, 2013
[ 12 ] U. C. Okoro and A.O. Ijeoma; Synthesis of new non-linear polycyclic diazaphenothiazine ring system. International Jour of Chem. 16, (4), 245-250, 2006
[ 13 ] Okafor C.O; A new type of angular phenothiazine ring system. Tetrahedron, 42 (10) 22771-80, 1986
[ 14 ] Okoro U.C., Synthesis of a new branched benzoxazinoazaphenothiazine ring system. Ind. J. Chem. 30B, (18), 22-24, 1991.