Disintegration Properties and Drug Release Profiles of Chondroitin Sulfate Films

Volume 4, Issue 2, April 2019     |     PP. 32-40      |     PDF (307 K)    |     Pub. Date: August 31, 2019
DOI:    208 Downloads     7052 Views  

Author(s)

Yoshifumi Murata, Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan
Yukako Maejima, Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan
Chieko Maida, Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan
Kyoko Kofuji, Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan

Abstract
Film dosage form (FD) prepared using water-soluble polymers is an excellent technique by which drugs can be delivered to local disease sites. In this study, FD was prepared with the sodium salt of chondroitin sulfate (CHS), a natural polysaccharide, by the casting method. The disintegration profile of FD was assessed and the dissolution profile of the model drug from the dosage form was investigated. FDs containing atropine sulfate were prepared by using 4−6% of CHS. When the FDs were brought in contact with physiological saline, they swelled quickly and disintegrated resulting in CHS release into the medium. The model drug dissolved immediately from the FDs and almost the entire amount of the drug incorporated in the FD was dissolved after 5 min. FD prepared with CHS is an attractive dosage form that can be used for local drug delivery.

Keywords
Sodium Chondroitin Sulfate, Film Dosage Form, Film Disintegration, Atropine Sulfate, Drug Release Profile

Cite this paper
Yoshifumi Murata, Yukako Maejima, Chieko Maida, Kyoko Kofuji, Disintegration Properties and Drug Release Profiles of Chondroitin Sulfate Films , SCIREA Journal of Materials. Volume 4, Issue 2, April 2019 | PP. 32-40.

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