Preparation of magnetic nano carrier for in-vitro delivery of methimazole drug complexed with polyethylene glycol in simulated gastric and simulated body fluids, optimizing by RSM

Volume 4, Issue 3, June 2019     |     PP. 82-105      |     PDF (967 K)    |     Pub. Date: August 5, 2019
DOI:    248 Downloads     6540 Views  

Author(s)

F. Torki, Department of Chemistry, Islamic Azad University, Shahreza Branch, Shahreza, Iran

Abstract
In this research, a magnetized core-shell was prepared by polymerization of pyrrole in the presence of Fe3O4 nanoparticles and was used as a drug carrier for methimazole. The drug was introduced to the carrier as methimazole-polyethylene glycol complex. The parameters affecting the synthesis of the carrier and the effect of pH on the release of the drug were optimized by response surface methodology. The drug and polyethylene glycol amounts were taken as numerical factors in five levels and the pH of the fluid as categorical factor in 2 levels (pH=1.2 for simulated gastric fluid and pH=7.4 for simulated body fluid) was considered. It was concluded that in SGF, slower releasing rate was obtained, and the release of the drug was controlled by PEG while the controlling effect of PEG in SBF was insignificant. The ANOVA results indicated the fitness of the model according to R2=0.9968. The model was statistically significant according to the F-value and p-value of 1585.72 and 0.0001 respectively. The F-value of La

Keywords
Magnetized nanocarrier; Drug delivery; Polypyrrole; Polyethylene glycol; Biocompatible; Methimazole

Cite this paper
F. Torki, Preparation of magnetic nano carrier for in-vitro delivery of methimazole drug complexed with polyethylene glycol in simulated gastric and simulated body fluids, optimizing by RSM , SCIREA Journal of Chemistry. Volume 4, Issue 3, June 2019 | PP. 82-105.

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